Matthew McConaughey
Cooper
Anne Hathaway
Brand
Michael Caine
Professor Brand
Jessica Chastain
Murph
Casey Affleck
Tom
Wes Bentley
Doyle
Topher Grace
Getty
Mackenzie Foy
Murph (10 Yrs.)
Ellen Burstyn
Murph (older)
John Lithgow
Donald
Bill Irwin
TARS (voice)
David Gyasi
Romilly
Timothée Chalamet
Tom (15 Yrs.)
Matt Damon
Mann
Josh Stewart
CASE (voice)
Leah Cairns
Lois
Liam Dickinson
Coop
Francis X. McCarthy
Boots
William Devane
Williams
Andrew Borba
Smith
Elyes Gabel
Administrator
David Oyelowo
School Principal
Collette Wolfe
Ms. Hanley
Jeff Hephner
Doctor
Russ Fega
Crew Chief
Lena Georgas
Nurse Practitioner
Brooke Smith
Nurse
Flora Nolan
Girl on Truck
Griffen Fraser
Boy on Truck
Kristian Van der Heyden
Scientist (uncredited)
William Patrick Brown
NASA employee (uncredited)
Benjamin Hardy
NASA Scientist (uncredited)
Joseph Oliveira
Astronaut (uncredited)
Alexander Michael Helisek
Construction boss (uncredited)
Rory Nolan
Little Boy in the hospital (uncredited)