Will Smith
Oscar (voice)
Robert De Niro
Don Lino (voice)
Renée Zellweger
Angie (voice)
Jack Black
Lenny (voice)
Angelina Jolie
Lola (voice)
Ziggy Marley
Ernie (voice)
Martin Scorsese
Sykes (voice)
David P. Smith
Crazy Joe (voice)
Doug E. Doug
Bernie (voice)
Michael Imperioli
Frankie (voice)
Vincent Pastore
Luca (voice)
Peter Falk
Don Feinberg (voice)
Katie Couric
Katie Current (voice)
Phil LaMarr
Prawn Shop Owner (voice)
Shelley Morrison
Mrs. Sanchez (voice)
David Soren
Shrimp / Worm / Starfish #1 / Killer Whale #2 (voice)
Bobb'e J. Thompson
Shortie #1 (voice)
Kamali Minter
Shortie #2 (voice)
Emily Lyon Segan
Shortie #3 (voice)
Lenny Venito
Giuseppe / Great White #1 (voice)
Saverio Guerra
Pontrelli (voice)
Mark Swift
Announcer (voice)
James Madio
Great White #2 / Hammerhead (voice)
Frank Vincent
Great White #3 (voice)
Joseph Siravo
Great White #5 (voice)
Steve Alterman
Messenger Fish / Tip Fish #2 (voice)
Jenifer Lewis
Motown Turtle (voice)
Sean Bishop
Tip Fish #1 / Great White #4 / Whale / Killer Whale #1 (voice)
James Ryan
Cashier / Oyster / Clown Whale (voice)
Latifa Ouaou
Whale Wash Co-Worker (voice)
David Yanover
Taxi Fish (voice)
Christina Aguilera
Christina (voice) (uncredited)
Missy Elliott
Missy (voice) (uncredited)